Drug interactions
Atropine iv / + Rimantadine
Severity: Minor
Atropine iv / and Rimantadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rimantadine may cause CNS effects such as dizziness, insomnia and confusion, while systemic atropine can cause confusion, agitation and delirium, especially in older patients. Combined use may add to central adverse effects, although the interaction is not well documented and atropine is usually given short term.
What this interaction means in plain words
Atropine iv / and Rimantadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS and anticholinergic effects; the mechanism is not firmly established.
What to do
Monitor mental status in older patients or those with renal impairment when atropine is given to a patient on rimantadine. Reduce the dose of rimantadine in renal impairment per labeling.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rimantadine
Frequently asked questions
Can I take Atropine iv / with Rimantadine?
MediHelp rates the interaction as minor. Atropine iv / and Rimantadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rimantadine may cause CNS effects such as dizziness, insomnia and confusion, while systemic atropine can cause confusion, agitation and delirium, especially in older patients. Combined use may add to central adverse effects, although the interaction is not well documented and atropine is usually given short term.
How serious is the interaction between Atropine iv / and Rimantadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mental status in older patients or those with renal impairment when atropine is given to a patient on rimantadine. Reduce the dose of rimantadine in renal impairment per labeling.
What other medicines interact with Rimantadine?
MediHelp also lists interactions of Rimantadine with, for example, Henbane, Glycopyrrolate, Glycopyrronium. The full list is on the Rimantadine page.
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