Drug interactions
Atropine iv / + Thioridazine
Severity: Moderate
Atropine iv / and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atropine and thioridazine both have antimuscarinic activity, so their combination can cause tachycardia, dry mouth, urinary retention, constipation and confusion. The effects are most important in older or susceptible patients.
What this interaction means in plain words
Atropine iv / and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor heart rate, mental status and urinary and bowel function. Reduce the atropine dose if anticholinergic toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Atropine iv / with Thioridazine?
MediHelp rates the interaction as moderate. Atropine iv / and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atropine and thioridazine both have antimuscarinic activity, so their combination can cause tachycardia, dry mouth, urinary retention, constipation and confusion. The effects are most important in older or susceptible patients.
How serious is the interaction between Atropine iv / and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, mental status and urinary and bowel function. Reduce the atropine dose if anticholinergic toxicity appears.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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