Drug interactions
Atropine iv / + Tiotropium
Severity: Moderate
Atropine iv / and Tiotropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atropine is a systemic antimuscarinic and can add to the anticholinergic effects of tiotropium. This may cause tachycardia, dry mouth, urinary retention and raised intraocular pressure.
What this interaction means in plain words
Atropine iv / and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor heart rate and for urinary retention or eye pain, especially in older patients and those with glaucoma. Use the lowest effective atropine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium
Frequently asked questions
Can I take Atropine iv / with Tiotropium?
MediHelp rates the interaction as moderate. Atropine iv / and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atropine is a systemic antimuscarinic and can add to the anticholinergic effects of tiotropium. This may cause tachycardia, dry mouth, urinary retention and raised intraocular pressure.
How serious is the interaction between Atropine iv / and Tiotropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and for urinary retention or eye pain, especially in older patients and those with glaucoma. Use the lowest effective atropine dose.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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