Drug interactions
Indacaterol-glycopyrronium + Tiotropium
Severity: Major
Indacaterol-glycopyrronium and Tiotropium: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are inhaled long-acting muscarinic antagonists, so combining them duplicates therapy and increases anticholinergic effects such as dry mouth, urinary retention and glaucoma risk without proven added benefit.
What this interaction means in plain words
Indacaterol-glycopyrronium and Tiotropium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol-glycopyrronium belongs to Respiratory; Tiotropium belongs to Respiratory.
Why it happens
Duplicate muscarinic receptor antagonism leading to additive anticholinergic exposure.
What to do
Avoid concurrent use and keep only one long-acting muscarinic antagonist. If a switch is made, stop the previous agent.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indacaterol-glycopyrronium and Tiotropium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Indacaterol-glycopyrronium
Other interactions of Tiotropium
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Tiotropium?
MediHelp rates the interaction as major. Indacaterol-glycopyrronium and Tiotropium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are inhaled long-acting muscarinic antagonists, so combining them duplicates therapy and increases anticholinergic effects such as dry mouth, urinary retention and glaucoma risk without proven added benefit.
How serious is the interaction between Indacaterol-glycopyrronium and Tiotropium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep only one long-acting muscarinic antagonist. If a switch is made, stop the previous agent.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
