Drug interactions
Tiotropium + Umeclidinium
Severity: Major
Tiotropium and Umeclidinium: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are long-acting inhaled antimuscarinic bronchodilators, so combining them duplicates therapy with no added benefit. It increases the risk of anticholinergic effects such as dry mouth, urinary retention and worsening of narrow-angle glaucoma.
What this interaction means in plain words
Tiotropium and Umeclidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tiotropium belongs to Respiratory; Umeclidinium belongs to Respiratory.
Why it happens
Duplicate antimuscarinic receptor blockade producing additive effects.
What to do
Do not use together; choose one long-acting antimuscarinic and discontinue the other.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Tiotropium and Umeclidinium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Umeclidinium
- Aclidinium + Umeclidinium Moderate
- Atropine iv / + Umeclidinium Moderate
- Atropine + Umeclidinium Moderate
- Belladonna alkaloids + Umeclidinium Moderate
- Bethanechol + Umeclidinium Moderate
- Dicyclomine + Umeclidinium Moderate
Other interactions of Tiotropium
Frequently asked questions
Can I take Tiotropium with Umeclidinium?
MediHelp rates the interaction as major. Tiotropium and Umeclidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are long-acting inhaled antimuscarinic bronchodilators, so combining them duplicates therapy with no added benefit. It increases the risk of anticholinergic effects such as dry mouth, urinary retention and worsening of narrow-angle glaucoma.
How serious is the interaction between Tiotropium and Umeclidinium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose one long-acting antimuscarinic and discontinue the other.
What other medicines interact with Umeclidinium?
MediHelp also lists interactions of Umeclidinium with, for example, Aclidinium, Atropine iv /, Atropine. The full list is on the Umeclidinium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
