Drug interactions
Atropine iv / + Umeclidinium-vilanterol
Severity: Moderate
Atropine iv / and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atropine is a systemic antimuscarinic and umeclidinium is an inhaled antimuscarinic, so they can add to anticholinergic effects. These include dry mouth, tachycardia, urinary retention, constipation and raised intraocular pressure.
What this interaction means in plain words
Atropine iv / and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic receptor blockade.
What to do
Monitor for urinary retention, tachycardia, visual symptoms and constipation, especially in older patients or those with glaucoma or prostatic hypertrophy. Use the lowest effective atropine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Frequently asked questions
Can I take Atropine iv / with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Atropine iv / and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atropine is a systemic antimuscarinic and umeclidinium is an inhaled antimuscarinic, so they can add to anticholinergic effects. These include dry mouth, tachycardia, urinary retention, constipation and raised intraocular pressure.
How serious is the interaction between Atropine iv / and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, tachycardia, visual symptoms and constipation, especially in older patients or those with glaucoma or prostatic hypertrophy. Use the lowest effective atropine dose.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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