Drug interactions
Axicabtagene ciloleucel + Cyclophosphamide
Severity: Moderate
Axicabtagene ciloleucel and Cyclophosphamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclophosphamide is part of the standard lymphodepletion given before axicabtagene ciloleucel, so the pairing is intended in that setting. Giving additional cyclophosphamide outside the planned regimen, or in the period around the infusion, can add to immunosuppression and infection risk and may impair CAR-T expansion.
What this interaction means in plain words
Axicabtagene ciloleucel and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axicabtagene ciloleucel belongs to Oncology; Cyclophosphamide belongs to Oncology.
Why it happens
Additive immunosuppression and lymphodepletion that can affect CAR-T cell expansion and persistence.
What to do
Use cyclophosphamide only as specified in the lymphodepleting regimen and avoid unplanned additional doses. Monitor for infection and cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Axicabtagene ciloleucel and Cyclophosphamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclophosphamide
Other interactions of Axicabtagene ciloleucel
Frequently asked questions
Can I take Axicabtagene ciloleucel with Cyclophosphamide?
MediHelp rates the interaction as moderate. Axicabtagene ciloleucel and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclophosphamide is part of the standard lymphodepletion given before axicabtagene ciloleucel, so the pairing is intended in that setting. Giving additional cyclophosphamide outside the planned regimen, or in the period around the infusion, can add to immunosuppression and infection risk and may impair CAR-T expansion.
How serious is the interaction between Axicabtagene ciloleucel and Cyclophosphamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use cyclophosphamide only as specified in the lymphodepleting regimen and avoid unplanned additional doses. Monitor for infection and cytopenias.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
