Drug interactions
Axicabtagene ciloleucel + Deflazacort
Severity: Moderate
Axicabtagene ciloleucel and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can impair CAR-T cell expansion and activity and add to infection risk. They are often needed to treat cytokine release syndrome or neurotoxicity, so this must be balanced.
What this interaction means in plain words
Axicabtagene ciloleucel and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axicabtagene ciloleucel belongs to Oncology; Deflazacort belongs to Miscellaneous.
Why it happens
Corticosteroid-mediated lymphocyte suppression may reduce CAR-T cell function and add immunosuppression.
What to do
Avoid prophylactic or chronic steroids where possible. Use them for cytokine release syndrome or neurotoxicity as clinically needed and monitor for infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Axicabtagene ciloleucel and Deflazacort, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Axicabtagene ciloleucel
Frequently asked questions
Can I take Axicabtagene ciloleucel with Deflazacort?
MediHelp rates the interaction as moderate. Axicabtagene ciloleucel and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can impair CAR-T cell expansion and activity and add to infection risk. They are often needed to treat cytokine release syndrome or neurotoxicity, so this must be balanced.
How serious is the interaction between Axicabtagene ciloleucel and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prophylactic or chronic steroids where possible. Use them for cytokine release syndrome or neurotoxicity as clinically needed and monitor for infection.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
