Drug interactions
Axicabtagene ciloleucel + Ifosfamide
Severity: Major
Axicabtagene ciloleucel and Ifosfamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide is myelosuppressive and immunosuppressive, and axicabtagene ciloleucel can cause prolonged cytopenias and infection risk. Concurrent use may add to infection risk and impair CAR-T cell collection or expansion.
What this interaction means in plain words
Axicabtagene ciloleucel and Ifosfamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axicabtagene ciloleucel belongs to Oncology; Ifosfamide belongs to Oncology.
Why it happens
Additive immunosuppression and myelosuppression; cytotoxic therapy may reduce CAR-T cell expansion.
What to do
Avoid chemotherapy other than planned lymphodepletion around CAR-T infusion and observe the washout before leukapheresis. Monitor blood counts and infection afterwards.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Axicabtagene ciloleucel
Frequently asked questions
Can I take Axicabtagene ciloleucel with Ifosfamide?
MediHelp rates the interaction as major. Axicabtagene ciloleucel and Ifosfamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ifosfamide is myelosuppressive and immunosuppressive, and axicabtagene ciloleucel can cause prolonged cytopenias and infection risk. Concurrent use may add to infection risk and impair CAR-T cell collection or expansion.
How serious is the interaction between Axicabtagene ciloleucel and Ifosfamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chemotherapy other than planned lymphodepletion around CAR-T infusion and observe the washout before leukapheresis. Monitor blood counts and infection afterwards.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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