Drug interactions
Axitinib + Cyclosporin
Severity: Moderate
Axitinib and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can increase axitinib exposure, which may worsen adverse effects such as hypertension, diarrhea, and hepatotoxicity. The effect is modest compared with strong CYP3A4 inhibitors.
What this interaction means in plain words
Axitinib and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Cyclosporin belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by cyclosporine reduces axitinib clearance.
What to do
Monitor blood pressure and tolerability, and reduce the axitinib dose if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Cyclosporin?
MediHelp rates the interaction as moderate. Axitinib and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine can increase axitinib exposure, which may worsen adverse effects such as hypertension, diarrhea, and hepatotoxicity. The effect is modest compared with strong CYP3A4 inhibitors.
How serious is the interaction between Axitinib and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and tolerability, and reduce the axitinib dose if adverse effects develop.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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