Drug interactions
Axitinib + Desvenlafaxine
Severity: Minor
Axitinib and Desvenlafaxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desvenlafaxine has little effect on CYP3A4, so a meaningful rise in axitinib levels is not expected. The legacy claim of CYP3A4 inhibition is not supported by known pharmacology.
What this interaction means in plain words
Axitinib and Desvenlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Desvenlafaxine belongs to Central Nervous System.
Why it happens
No established mechanism; desvenlafaxine is not a clinically relevant CYP3A4 inhibitor.
What to do
No specific adjustment is required; monitor for usual axitinib adverse effects such as hypertension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Desvenlafaxine?
MediHelp rates the interaction as minor. Axitinib and Desvenlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Desvenlafaxine has little effect on CYP3A4, so a meaningful rise in axitinib levels is not expected. The legacy claim of CYP3A4 inhibition is not supported by known pharmacology.
How serious is the interaction between Axitinib and Desvenlafaxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific adjustment is required; monitor for usual axitinib adverse effects such as hypertension.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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