Drug interactions
Axitinib + Dexamethasone-neomycin-polymyxin
Severity: Moderate
Axitinib and Dexamethasone-neomycin-polymyxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone is a CYP3A4 inducer and may reduce axitinib exposure. This could lessen antitumor efficacy. Induction is dose-dependent and is minor with topical use of this combination product.
What this interaction means in plain words
Axitinib and Dexamethasone-neomycin-polymyxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial.
Why it happens
CYP3A4 induction by dexamethasone increases axitinib metabolism.
What to do
For systemic dexamethasone, monitor for reduced axitinib response and consider alternatives where feasible. No action is generally needed with topical use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Dexamethasone-neomycin-polymyxin?
MediHelp rates the interaction as moderate. Axitinib and Dexamethasone-neomycin-polymyxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone is a CYP3A4 inducer and may reduce axitinib exposure. This could lessen antitumor efficacy. Induction is dose-dependent and is minor with topical use of this combination product.
How serious is the interaction between Axitinib and Dexamethasone-neomycin-polymyxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For systemic dexamethasone, monitor for reduced axitinib response and consider alternatives where feasible. No action is generally needed with topical use.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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