Drug interactions
Axitinib + Dexamethasone
Severity: Moderate
Axitinib and Dexamethasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone is a weak to moderate CYP3A4 inducer and may lower axitinib exposure, potentially reducing antitumor efficacy. The effect is less pronounced than with strong inducers such as rifampicin.
What this interaction means in plain words
Axitinib and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Dexamethasone belongs to Endocrine.
Why it happens
Dexamethasone induces CYP3A4, increasing the metabolism of axitinib, which is mainly a CYP3A4/5 substrate.
What to do
Monitor for reduced response to axitinib when dexamethasone is given for prolonged courses. Short antiemetic courses rarely need action, but avoid strong inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Dexamethasone?
MediHelp rates the interaction as moderate. Axitinib and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone is a weak to moderate CYP3A4 inducer and may lower axitinib exposure, potentially reducing antitumor efficacy. The effect is less pronounced than with strong inducers such as rifampicin.
How serious is the interaction between Axitinib and Dexamethasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to axitinib when dexamethasone is given for prolonged courses. Short antiemetic courses rarely need action, but avoid strong inducers.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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