Drug interactions
Axitinib + Docetaxel
Severity: Minor
Axitinib and Docetaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Docetaxel is not a meaningful CYP3A4 inhibitor, so a clinically relevant rise in axitinib exposure is unlikely. The pair is used together in trials without a recognized pharmacokinetic interaction.
What this interaction means in plain words
Axitinib and Docetaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Docetaxel belongs to Oncology.
Why it happens
No established mechanism; docetaxel is a CYP3A4 substrate rather than an inhibitor.
What to do
No dose adjustment is needed; monitor for the usual toxicities of both drugs such as hypertension and neutropenia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Docetaxel
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Docetaxel?
MediHelp rates the interaction as minor. Axitinib and Docetaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Docetaxel is not a meaningful CYP3A4 inhibitor, so a clinically relevant rise in axitinib exposure is unlikely. The pair is used together in trials without a recognized pharmacokinetic interaction.
How serious is the interaction between Axitinib and Docetaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for the usual toxicities of both drugs such as hypertension and neutropenia.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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