Drug interactions
Axitinib + Erythromycin
Severity: Moderate
Axitinib and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin, a moderate CYP3A4 inhibitor, can raise axitinib exposure. Higher axitinib levels may increase adverse effects such as hypertension, diarrhea, and bleeding or thrombotic events.
What this interaction means in plain words
Axitinib and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Erythromycin belongs to Anti Bacterial.
Why it happens
Erythromycin inhibits CYP3A4-mediated metabolism of axitinib, reducing its clearance.
What to do
Prefer a non-interacting antibiotic such as azithromycin if possible. If coadministration is required, monitor blood pressure and tolerability and reduce the axitinib dose if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Erythromycin?
MediHelp rates the interaction as moderate. Axitinib and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin, a moderate CYP3A4 inhibitor, can raise axitinib exposure. Higher axitinib levels may increase adverse effects such as hypertension, diarrhea, and bleeding or thrombotic events.
How serious is the interaction between Axitinib and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-interacting antibiotic such as azithromycin if possible. If coadministration is required, monitor blood pressure and tolerability and reduce the axitinib dose if adverse effects develop.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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