Drug interactions
Axitinib + Etrasimod
Severity: Moderate
Axitinib and Etrasimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod lowers circulating lymphocytes, and axitinib is an antineoplastic agent; combined use has not been studied and may add to infection risk. The immunosuppressive effect of etrasimod can persist for weeks after stopping.
What this interaction means in plain words
Axitinib and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Etrasimod sequesters lymphocytes via S1P receptor modulation, which may add to the effects of other antineoplastic therapy; this is pharmacodynamic and not well established for axitinib.
What to do
Monitor for infection and check blood counts, and weigh benefit against risk before combining.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Axitinib with Etrasimod?
MediHelp rates the interaction as moderate. Axitinib and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod lowers circulating lymphocytes, and axitinib is an antineoplastic agent; combined use has not been studied and may add to infection risk. The immunosuppressive effect of etrasimod can persist for weeks after stopping.
How serious is the interaction between Axitinib and Etrasimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and check blood counts, and weigh benefit against risk before combining.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
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