Drug interactions
Axitinib + Glyburide-metformin
Severity: Minor
Axitinib and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide is not a recognized clinically relevant CYP3A4 inhibitor, so a meaningful rise in axitinib levels is not expected. The interaction is largely theoretical.
What this interaction means in plain words
Axitinib and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Glyburide-metformin belongs to Endocrine.
Why it happens
No well-established mechanism; weak CYP3A4 inhibition by glyburide has been proposed only theoretically.
What to do
No action is needed beyond routine monitoring of axitinib tolerability, such as blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Glyburide-metformin?
MediHelp rates the interaction as minor. Axitinib and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glyburide is not a recognized clinically relevant CYP3A4 inhibitor, so a meaningful rise in axitinib levels is not expected. The interaction is largely theoretical.
How serious is the interaction between Axitinib and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond routine monitoring of axitinib tolerability, such as blood pressure.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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