Drug interactions
Axitinib + Istradefylline
Severity: Moderate
Axitinib and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher doses (40 mg/day) istradefylline inhibits CYP3A4 and can increase exposure to CYP3A4 substrates such as axitinib. This may heighten axitinib adverse effects including hypertension and diarrhea.
What this interaction means in plain words
Axitinib and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline at higher doses inhibits CYP3A4, reducing axitinib clearance.
What to do
Monitor blood pressure and tolerability, and consider lowering the axitinib dose if istradefylline 40 mg/day is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Axitinib with Istradefylline?
MediHelp rates the interaction as moderate. Axitinib and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At higher doses (40 mg/day) istradefylline inhibits CYP3A4 and can increase exposure to CYP3A4 substrates such as axitinib. This may heighten axitinib adverse effects including hypertension and diarrhea.
How serious is the interaction between Axitinib and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and tolerability, and consider lowering the axitinib dose if istradefylline 40 mg/day is used.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
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