Drug interactions
Axitinib + Ivosidenib
Severity: Moderate
Axitinib and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib can lower axitinib concentrations, which may reduce its antitumor efficacy. The effect is likely to develop gradually as enzyme induction builds.
What this interaction means in plain words
Axitinib and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP3A4, increasing axitinib metabolism.
What to do
Consider alternatives that do not induce CYP3A4. If both are required, monitor for loss of tumor response and consider axitinib dose titration guided by tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Axitinib with Ivosidenib?
MediHelp rates the interaction as moderate. Axitinib and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib can lower axitinib concentrations, which may reduce its antitumor efficacy. The effect is likely to develop gradually as enzyme induction builds.
How serious is the interaction between Axitinib and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider alternatives that do not induce CYP3A4. If both are required, monitor for loss of tumor response and consider axitinib dose titration guided by tolerability.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
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