Drug interactions
Axitinib + Larotrectinib
Severity: Minor
Axitinib and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a weak CYP3A4 inhibitor in vitro and might slightly raise axitinib levels. A clinically significant effect is not established.
What this interaction means in plain words
Axitinib and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Larotrectinib belongs to Oncology.
Why it happens
Larotrectinib may weakly inhibit CYP3A4; the effect on axitinib is not well characterized.
What to do
No empiric dose change is needed. Monitor for axitinib adverse effects such as hypertension and diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Axitinib with Larotrectinib?
MediHelp rates the interaction as minor. Axitinib and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a weak CYP3A4 inhibitor in vitro and might slightly raise axitinib levels. A clinically significant effect is not established.
How serious is the interaction between Axitinib and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor for axitinib adverse effects such as hypertension and diarrhea.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
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