Drug interactions
Axitinib + Nifedipine
Severity: Minor
Axitinib and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Axitinib is metabolized mainly by CYP3A4, and nifedipine is only a weak inhibitor, so any rise in axitinib exposure is likely small. Axitinib itself can raise blood pressure, which may complicate antihypertensive therapy.
What this interaction means in plain words
Axitinib and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Nifedipine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by nifedipine reducing axitinib metabolism.
What to do
No dose adjustment is usually needed. Monitor blood pressure and axitinib adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Axitinib and Nifedipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Nifedipine
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Nifedipine?
MediHelp rates the interaction as minor. Axitinib and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Axitinib is metabolized mainly by CYP3A4, and nifedipine is only a weak inhibitor, so any rise in axitinib exposure is likely small. Axitinib itself can raise blood pressure, which may complicate antihypertensive therapy.
How serious is the interaction between Axitinib and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor blood pressure and axitinib adverse effects.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
