Drug interactions
Axitinib + Pazopanib
Severity: Moderate
Axitinib and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib is a weak CYP3A4 inhibitor and could modestly raise axitinib exposure. Both drugs also cause hypertension and hepatotoxicity, so overlapping toxicity is possible.
What this interaction means in plain words
Axitinib and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Pazopanib belongs to Oncology.
Why it happens
Pazopanib weakly inhibits CYP3A4, reducing axitinib clearance, with additive pharmacodynamic toxicity.
What to do
Monitor blood pressure and liver function and watch for axitinib adverse effects. Reduce the axitinib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Pazopanib?
MediHelp rates the interaction as moderate. Axitinib and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib is a weak CYP3A4 inhibitor and could modestly raise axitinib exposure. Both drugs also cause hypertension and hepatotoxicity, so overlapping toxicity is possible.
How serious is the interaction between Axitinib and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and liver function and watch for axitinib adverse effects. Reduce the axitinib dose if toxicity develops.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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