Drug interactions
Azathioprine + Cholera vaccine
Severity: Moderate
Azathioprine and Cholera vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azathioprine suppresses lymphocyte function and can blunt the antibody response to cholera vaccine. Protection may be incomplete in treated patients.
What this interaction means in plain words
Azathioprine and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Purine antimetabolite immunosuppression reduces antigen-specific immune responses.
What to do
Vaccinate before starting azathioprine when possible. Continue food and water precautions in endemic areas since immunity may be reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Azathioprine with Cholera vaccine?
MediHelp rates the interaction as moderate. Azathioprine and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azathioprine suppresses lymphocyte function and can blunt the antibody response to cholera vaccine. Protection may be incomplete in treated patients.
How serious is the interaction between Azathioprine and Cholera vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting azathioprine when possible. Continue food and water precautions in endemic areas since immunity may be reduced.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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