Drug interactions
Azathioprine + Ciltacabtagene autoleucel
Severity: Major
Azathioprine and Ciltacabtagene autoleucel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azathioprine may impair T-cell function and reduce CAR-T cell expansion and efficacy. It also increases the risk of infection during the cytopenic period after CAR-T therapy.
What this interaction means in plain words
Azathioprine and Ciltacabtagene autoleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Ciltacabtagene autoleucel belongs to Miscellaneous.
Why it happens
Immunosuppressive antimetabolite activity against lymphocytes may reduce CAR-T cell expansion and persistence.
What to do
Discontinue azathioprine before leukapheresis and infusion as directed by the treating center. Monitor for infection if it must continue.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azathioprine and Ciltacabtagene autoleucel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine live Contraindicated
Other interactions of Ciltacabtagene autoleucel
Frequently asked questions
Can I take Azathioprine with Ciltacabtagene autoleucel?
MediHelp rates the interaction as major. Azathioprine and Ciltacabtagene autoleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azathioprine may impair T-cell function and reduce CAR-T cell expansion and efficacy. It also increases the risk of infection during the cytopenic period after CAR-T therapy.
How serious is the interaction between Azathioprine and Ciltacabtagene autoleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discontinue azathioprine before leukapheresis and infusion as directed by the treating center. Monitor for infection if it must continue.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
