Drug interactions
Azathioprine + Hepatitis a / b vaccine
Severity: Moderate
Azathioprine and Hepatitis a / b vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azathioprine can lower seroconversion and antibody titres after this inactivated vaccine. Patients may remain unprotected despite a full course.
What this interaction means in plain words
Azathioprine and Hepatitis a / b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Azathioprine impairs lymphocyte proliferation and humoral responses to vaccination.
What to do
Vaccinate, ideally before immunosuppression. Check anti-HBs and anti-HAV after the series and revaccinate or boost if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Azathioprine with Hepatitis a / b vaccine?
MediHelp rates the interaction as moderate. Azathioprine and Hepatitis a / b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azathioprine can lower seroconversion and antibody titres after this inactivated vaccine. Patients may remain unprotected despite a full course.
How serious is the interaction between Azathioprine and Hepatitis a / b vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate, ideally before immunosuppression. Check anti-HBs and anti-HAV after the series and revaccinate or boost if the response is inadequate.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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