Drug interactions
Azathioprine + Human papillomavirus vaccine nonavalent
Severity: Minor
Azathioprine and Human papillomavirus vaccine nonavalent: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azathioprine may reduce the antibody response to HPV vaccine, leaving protection weaker than expected. The vaccine is non-live and safe to give.
What this interaction means in plain words
Azathioprine and Human papillomavirus vaccine nonavalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Immunosuppression from azathioprine reduces lymphocyte proliferation and antibody production after vaccination.
What to do
Do not withhold vaccination; complete the full three-dose schedule recommended for immunocompromised patients. Where possible vaccinate before starting azathioprine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Azathioprine with Human papillomavirus vaccine nonavalent?
MediHelp rates the interaction as minor. Azathioprine and Human papillomavirus vaccine nonavalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azathioprine may reduce the antibody response to HPV vaccine, leaving protection weaker than expected. The vaccine is non-live and safe to give.
How serious is the interaction between Azathioprine and Human papillomavirus vaccine nonavalent?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not withhold vaccination; complete the full three-dose schedule recommended for immunocompromised patients. Where possible vaccinate before starting azathioprine.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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