Drug interactions
Azathioprine + Human papillomavirus vaccine quadrivalent
Severity: Moderate
Azathioprine and Human papillomavirus vaccine quadrivalent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azathioprine suppresses lymphocyte proliferation and may blunt the antibody response to the HPV vaccine. The vaccine is non-live, so it is safe to give, but protection may be lower or shorter-lived.
What this interaction means in plain words
Azathioprine and Human papillomavirus vaccine quadrivalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Purine antimetabolite immunosuppression reduces B- and T-cell responses to vaccine antigens.
What to do
Do not withhold the vaccine; complete the full series, ideally before starting immunosuppression when feasible. Consider checking antibody response where relevant and do not assume full protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Azathioprine with Human papillomavirus vaccine quadrivalent?
MediHelp rates the interaction as moderate. Azathioprine and Human papillomavirus vaccine quadrivalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azathioprine suppresses lymphocyte proliferation and may blunt the antibody response to the HPV vaccine. The vaccine is non-live, so it is safe to give, but protection may be lower or shorter-lived.
How serious is the interaction between Azathioprine and Human papillomavirus vaccine quadrivalent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not withhold the vaccine; complete the full series, ideally before starting immunosuppression when feasible. Consider checking antibody response where relevant and do not assume full protection.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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