Drug interactions
Azathioprine + Influenza virus vaccine quadrivalent cell-cultured
Severity: Moderate
Azathioprine and Influenza virus vaccine quadrivalent cell-cultured: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azathioprine may blunt the immune response to this inactivated cell-cultured influenza vaccine. The vaccine is still worthwhile because influenza is more dangerous in immunosuppressed patients.
What this interaction means in plain words
Azathioprine and Influenza virus vaccine quadrivalent cell-cultured can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Azathioprine impairs lymphocyte proliferation and humoral responses to vaccination.
What to do
Vaccinate every season. Reinforce other preventive measures given the possibility of reduced protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Azathioprine with Influenza virus vaccine quadrivalent cell-cultured?
MediHelp rates the interaction as moderate. Azathioprine and Influenza virus vaccine quadrivalent cell-cultured can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azathioprine may blunt the immune response to this inactivated cell-cultured influenza vaccine. The vaccine is still worthwhile because influenza is more dangerous in immunosuppressed patients.
How serious is the interaction between Azathioprine and Influenza virus vaccine quadrivalent cell-cultured?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate every season. Reinforce other preventive measures given the possibility of reduced protection.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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