Drug interactions
Azathioprine + Influenza virus vaccine trivalent
Severity: Moderate
Azathioprine and Influenza virus vaccine trivalent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azathioprine may reduce the antibody response to inactivated trivalent influenza vaccine. Vaccination is still advised, as the vaccine carries no infection risk.
What this interaction means in plain words
Azathioprine and Influenza virus vaccine trivalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Azathioprine impairs lymphocyte proliferation and humoral responses to vaccination.
What to do
Give the inactivated vaccine each season. Confirm the product is not the live intranasal formulation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Azathioprine with Influenza virus vaccine trivalent?
MediHelp rates the interaction as moderate. Azathioprine and Influenza virus vaccine trivalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azathioprine may reduce the antibody response to inactivated trivalent influenza vaccine. Vaccination is still advised, as the vaccine carries no infection risk.
How serious is the interaction between Azathioprine and Influenza virus vaccine trivalent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the inactivated vaccine each season. Confirm the product is not the live intranasal formulation.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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