Drug interactions
Azathioprine + Mipomersen
Severity: Moderate
Azathioprine and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise liver enzymes and cause hepatotoxicity, so using them together may add to liver injury risk. Mipomersen carries a boxed warning for hepatotoxicity, which makes any added hepatic burden clinically relevant.
What this interaction means in plain words
Azathioprine and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxicity through separate mechanisms (hepatic fat accumulation and transaminase elevation with mipomersen; idiosyncratic and dose-related liver injury with azathioprine).
What to do
Check ALT, AST and bilirubin before starting and at regular intervals during combined use. Interrupt one or both drugs if transaminases rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Azathioprine with Mipomersen?
MediHelp rates the interaction as moderate. Azathioprine and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can raise liver enzymes and cause hepatotoxicity, so using them together may add to liver injury risk. Mipomersen carries a boxed warning for hepatotoxicity, which makes any added hepatic burden clinically relevant.
How serious is the interaction between Azathioprine and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ALT, AST and bilirubin before starting and at regular intervals during combined use. Interrupt one or both drugs if transaminases rise significantly.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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