Drug interactions
Azathioprine + Muromonab cd3
Severity: Major
Azathioprine and Muromonab cd3: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress T-cell function, and combined use increases the risk of serious infections and lymphoproliferative disorders. This combination was historically used in transplant regimens with intensive monitoring, and muromonab is now discontinued.
What this interaction means in plain words
Azathioprine and Muromonab cd3 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression from T-cell depletion plus inhibition of purine synthesis in lymphocytes.
What to do
Use only within a defined transplant protocol with dose adjustment of maintenance immunosuppressants. Monitor for infection, white cell count and signs of lymphoproliferative disease.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Azathioprine with Muromonab cd3?
MediHelp rates the interaction as major. Azathioprine and Muromonab cd3 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents suppress T-cell function, and combined use increases the risk of serious infections and lymphoproliferative disorders. This combination was historically used in transplant regimens with intensive monitoring, and muromonab is now discontinued.
How serious is the interaction between Azathioprine and Muromonab cd3?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only within a defined transplant protocol with dose adjustment of maintenance immunosuppressants. Monitor for infection, white cell count and signs of lymphoproliferative disease.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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