Drug interactions
Azathioprine + Poliovirus vaccine inactivated
Severity: Moderate
Azathioprine and Poliovirus vaccine inactivated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azathioprine may reduce the immune response to inactivated poliovirus vaccine. The vaccine is safe to administer but protection may be suboptimal.
What this interaction means in plain words
Azathioprine and Poliovirus vaccine inactivated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Azathioprine-induced immunosuppression impairs antibody responses to vaccine antigens.
What to do
Give inactivated polio vaccine before azathioprine when possible. If given during therapy, consider serology or revaccination after immune recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Azathioprine with Poliovirus vaccine inactivated?
MediHelp rates the interaction as moderate. Azathioprine and Poliovirus vaccine inactivated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azathioprine may reduce the immune response to inactivated poliovirus vaccine. The vaccine is safe to administer but protection may be suboptimal.
How serious is the interaction between Azathioprine and Poliovirus vaccine inactivated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give inactivated polio vaccine before azathioprine when possible. If given during therapy, consider serology or revaccination after immune recovery.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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