Drug interactions
Azathioprine + Rotavirus oral vaccine live
Severity: Contraindicated
Azathioprine and Rotavirus oral vaccine live: contraindicated interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live rotavirus vaccine could cause prolonged or severe vaccine-strain infection in an immunosuppressed patient. Vaccine response may also be reduced.
What this interaction means in plain words
Azathioprine and Rotavirus oral vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Azathioprine impairs cellular immunity, allowing replication of live attenuated virus.
What to do
Avoid the live vaccine in patients on azathioprine, including infants exposed in utero where recommended by local guidance. Seek specialist advice about timing.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Azathioprine with Rotavirus oral vaccine live?
MediHelp rates the interaction as contraindicated. Azathioprine and Rotavirus oral vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live rotavirus vaccine could cause prolonged or severe vaccine-strain infection in an immunosuppressed patient. Vaccine response may also be reduced.
How serious is the interaction between Azathioprine and Rotavirus oral vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live vaccine in patients on azathioprine, including infants exposed in utero where recommended by local guidance. Seek specialist advice about timing.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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