Drug interactions
Azathioprine + Tetanus toxoid adsorbed or fluid
Severity: Moderate
Azathioprine and Tetanus toxoid adsorbed or fluid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azathioprine can blunt the antibody response to tetanus toxoid. Protective titres may be lower or wane faster, although the vaccine is safe.
What this interaction means in plain words
Azathioprine and Tetanus toxoid adsorbed or fluid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Azathioprine impairs lymphocyte proliferation and humoral responses to vaccination.
What to do
Continue routine boosters and give tetanus immunoglobulin for high-risk wounds when indicated. Do not withhold the vaccine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Azathioprine with Tetanus toxoid adsorbed or fluid?
MediHelp rates the interaction as moderate. Azathioprine and Tetanus toxoid adsorbed or fluid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azathioprine can blunt the antibody response to tetanus toxoid. Protective titres may be lower or wane faster, although the vaccine is safe.
How serious is the interaction between Azathioprine and Tetanus toxoid adsorbed or fluid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue routine boosters and give tetanus immunoglobulin for high-risk wounds when indicated. Do not withhold the vaccine.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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