Drug interactions
Azelastine + Chloral hydrate
Severity: Moderate
Azelastine and Chloral hydrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloral hydrate is a sedative-hypnotic, and azelastine may contribute additional drowsiness. Together they can deepen sedation and impair psychomotor function.
What this interaction means in plain words
Azelastine and Chloral hydrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Chloral hydrate belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1-antagonism and GABA-A potentiation by the chloral hydrate metabolite trichloroethanol.
What to do
Monitor for excessive sedation and avoid alcohol. Consider a non-sedating antihistamine if treatment is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Frequently asked questions
Can I take Azelastine with Chloral hydrate?
MediHelp rates the interaction as moderate. Azelastine and Chloral hydrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloral hydrate is a sedative-hypnotic, and azelastine may contribute additional drowsiness. Together they can deepen sedation and impair psychomotor function.
How serious is the interaction between Azelastine and Chloral hydrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and avoid alcohol. Consider a non-sedating antihistamine if treatment is needed.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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