Drug interactions
Azelastine + Clozapine
Severity: Moderate
Azelastine and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedating, so concurrent use may produce excessive drowsiness and impaired alertness. Clozapine can also cause orthostatic hypotension and respiratory depression, which may be worsened by additional CNS depression.
What this interaction means in plain words
Azelastine and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Clozapine belongs to Central Nervous System.
Why it happens
Additive CNS depression through antihistaminic (H1) effects of both drugs.
What to do
Monitor sedation and blood pressure, especially when starting azelastine or raising doses. Counsel the patient on avoiding driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Azelastine with Clozapine?
MediHelp rates the interaction as moderate. Azelastine and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sedating, so concurrent use may produce excessive drowsiness and impaired alertness. Clozapine can also cause orthostatic hypotension and respiratory depression, which may be worsened by additional CNS depression.
How serious is the interaction between Azelastine and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, especially when starting azelastine or raising doses. Counsel the patient on avoiding driving and alcohol.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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