Drug interactions
Azelastine + Cyclobenzaprine
Severity: Moderate
Azelastine and Cyclobenzaprine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is a sedating muscle relaxant structurally related to tricyclic antidepressants. Together with azelastine, drowsiness, dizziness and impaired alertness may be increased.
What this interaction means in plain words
Azelastine and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Cyclobenzaprine belongs to Musculoskeletal.
Why it happens
Additive CNS depression and antihistaminic effects.
What to do
Counsel the patient to avoid driving and alcohol until the response is known. Reduce the cyclobenzaprine dose or stop azelastine if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Azelastine with Cyclobenzaprine?
MediHelp rates the interaction as moderate. Azelastine and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine is a sedating muscle relaxant structurally related to tricyclic antidepressants. Together with azelastine, drowsiness, dizziness and impaired alertness may be increased.
How serious is the interaction between Azelastine and Cyclobenzaprine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to avoid driving and alcohol until the response is known. Reduce the cyclobenzaprine dose or stop azelastine if sedation is excessive.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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