Drug interactions
Azelastine + Cyproheptadine
Severity: Minor
Azelastine and Cyproheptadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral cyproheptadine combined with azelastine, particularly the nasal spray with some systemic absorption, can add to drowsiness. Duplicate antihistamine therapy adds little benefit.
What this interaction means in plain words
Azelastine and Cyproheptadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine belongs to Respiratory; Cyproheptadine belongs to Respiratory.
Why it happens
Additive H1-receptor antagonism and CNS depression.
What to do
Avoid duplicate antihistamine therapy where possible and warn the patient about drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Azelastine
Frequently asked questions
Can I take Azelastine with Cyproheptadine?
MediHelp rates the interaction as minor. Azelastine and Cyproheptadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral cyproheptadine combined with azelastine, particularly the nasal spray with some systemic absorption, can add to drowsiness. Duplicate antihistamine therapy adds little benefit.
How serious is the interaction between Azelastine and Cyproheptadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate antihistamine therapy where possible and warn the patient about drowsiness.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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