Drug interactions
Azelastine + Dimenhydrinate
Severity: Moderate
Azelastine and Dimenhydrinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate is a sedating antihistamine, so combining it with azelastine may markedly increase drowsiness and anticholinergic effects. This can impair alertness and coordination.
What this interaction means in plain words
Azelastine and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Dimenhydrinate belongs to Respiratory.
Why it happens
Additive H1-antihistamine mediated CNS depression.
What to do
Avoid combining where possible and counsel against driving. Monitor older patients for confusion and urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Azelastine with Dimenhydrinate?
MediHelp rates the interaction as moderate. Azelastine and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate is a sedating antihistamine, so combining it with azelastine may markedly increase drowsiness and anticholinergic effects. This can impair alertness and coordination.
How serious is the interaction between Azelastine and Dimenhydrinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and counsel against driving. Monitor older patients for confusion and urinary retention.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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