Drug interactions
Azelastine + Diphenoxylate-atropine
Severity: Minor
Azelastine and Diphenoxylate-atropine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine, particularly nasal or oral forms, can cause drowsiness and may add to sedation from diphenoxylate. Systemic exposure from nasal use is modest but not zero.
What this interaction means in plain words
Azelastine and Diphenoxylate-atropine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine belongs to Respiratory; Diphenoxylate-atropine belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depressant effects of H1 antagonism and opioid agonism.
What to do
Counsel on drowsiness and avoid alcohol or other sedatives.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Azelastine
Frequently asked questions
Can I take Azelastine with Diphenoxylate-atropine?
MediHelp rates the interaction as minor. Azelastine and Diphenoxylate-atropine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azelastine, particularly nasal or oral forms, can cause drowsiness and may add to sedation from diphenoxylate. Systemic exposure from nasal use is modest but not zero.
How serious is the interaction between Azelastine and Diphenoxylate-atropine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on drowsiness and avoid alcohol or other sedatives.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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