Drug interactions
Azelastine + Dosulepin
Severity: Moderate
Azelastine and Dosulepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating tricyclic antidepressant with anticholinergic properties. With azelastine, drowsiness and impaired alertness may increase.
What this interaction means in plain words
Azelastine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Dosulepin belongs to Central Nervous System.
Why it happens
Additive CNS depression and antihistaminic or anticholinergic effects.
What to do
Counsel the patient on sedation and avoiding driving or alcohol. Monitor older patients for confusion and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Azelastine with Dosulepin?
MediHelp rates the interaction as moderate. Azelastine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating tricyclic antidepressant with anticholinergic properties. With azelastine, drowsiness and impaired alertness may increase.
How serious is the interaction between Azelastine and Dosulepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on sedation and avoiding driving or alcohol. Monitor older patients for confusion and anticholinergic effects.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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