Drug interactions
Azelastine + Doxylamine
Severity: Moderate
Azelastine and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a strongly sedating antihistamine often used as a sleep aid. With azelastine, excessive drowsiness and next-day impairment may occur.
What this interaction means in plain words
Azelastine and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Doxylamine belongs to Respiratory.
Why it happens
Additive H1-antihistamine mediated CNS depression.
What to do
Avoid taking both together where possible and counsel against driving. Use a non-sedating alternative if an additional antihistamine is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azelastine and Doxylamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Azelastine
Other interactions of Doxylamine
Frequently asked questions
Can I take Azelastine with Doxylamine?
MediHelp rates the interaction as moderate. Azelastine and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a strongly sedating antihistamine often used as a sleep aid. With azelastine, excessive drowsiness and next-day impairment may occur.
How serious is the interaction between Azelastine and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking both together where possible and counsel against driving. Use a non-sedating alternative if an additional antihistamine is needed.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
