Drug interactions
Azelastine + Lofexidine
Severity: Moderate
Azelastine and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, and lofexidine also lowers blood pressure and heart rate. Combined use may increase sedation, dizziness and impairment of alertness.
What this interaction means in plain words
Azelastine and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Lofexidine belongs to Central Nervous System.
Why it happens
Additive CNS depression from sedating antihistamine effect and central alpha-2 adrenergic agonism.
What to do
Monitor for excessive sedation and hypotension, particularly at initiation and after dose increases. Counsel the patient to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Azelastine with Lofexidine?
MediHelp rates the interaction as moderate. Azelastine and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness, and lofexidine also lowers blood pressure and heart rate. Combined use may increase sedation, dizziness and impairment of alertness.
How serious is the interaction between Azelastine and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and hypotension, particularly at initiation and after dose increases. Counsel the patient to avoid driving until the response is known.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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