Drug interactions
Azelastine + Lorazepam
Severity: Moderate
Azelastine and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine, especially in oral or heavily absorbed forms, can add to the sedative effect of lorazepam. This can impair alertness, coordination and psychomotor performance, increasing the risk of falls and accidents.
What this interaction means in plain words
Azelastine and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through H1-receptor antagonism and GABA-A potentiation.
What to do
Monitor for excess drowsiness and consider the lowest effective lorazepam dose. Warn patients against driving and alcohol use, and take extra care in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Lorazepam
Frequently asked questions
Can I take Azelastine with Lorazepam?
MediHelp rates the interaction as moderate. Azelastine and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azelastine, especially in oral or heavily absorbed forms, can add to the sedative effect of lorazepam. This can impair alertness, coordination and psychomotor performance, increasing the risk of falls and accidents.
How serious is the interaction between Azelastine and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess drowsiness and consider the lowest effective lorazepam dose. Warn patients against driving and alcohol use, and take extra care in older adults.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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