Drug interactions
Azelastine + Mavacamten
Severity: Moderate
Azelastine and Mavacamten: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is cleared partly through CYP2C19, and azelastine is listed as a weak inhibitor of this enzyme, so mavacamten exposure may rise modestly. Higher exposure could deepen the reduction in left ventricular ejection fraction and raise the risk of heart failure symptoms.
What this interaction means in plain words
Azelastine and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Mavacamten belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP2C19-mediated metabolism of mavacamten by azelastine.
What to do
Monitor left ventricular ejection fraction and clinical status when azelastine is started or stopped in a patient on mavacamten. Follow the mavacamten echocardiographic monitoring schedule and adjust the dose if ejection fraction falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Azelastine with Mavacamten?
MediHelp rates the interaction as moderate. Azelastine and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mavacamten is cleared partly through CYP2C19, and azelastine is listed as a weak inhibitor of this enzyme, so mavacamten exposure may rise modestly. Higher exposure could deepen the reduction in left ventricular ejection fraction and raise the risk of heart failure symptoms.
How serious is the interaction between Azelastine and Mavacamten?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor left ventricular ejection fraction and clinical status when azelastine is started or stopped in a patient on mavacamten. Follow the mavacamten echocardiographic monitoring schedule and adjust the dose if ejection fraction falls.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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