Drug interactions
Azelastine + Nortriptyline
Severity: Moderate
Azelastine and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nortriptyline has sedative and anticholinergic properties that can add to azelastine drowsiness. This may lead to impaired alertness, dizziness and anticholinergic burden.
What this interaction means in plain words
Azelastine and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive CNS depression from combined H1-receptor antagonism.
What to do
Monitor for oversedation and anticholinergic effects, especially in older adults. Counsel on driving and alcohol avoidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Azelastine with Nortriptyline?
MediHelp rates the interaction as moderate. Azelastine and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nortriptyline has sedative and anticholinergic properties that can add to azelastine drowsiness. This may lead to impaired alertness, dizziness and anticholinergic burden.
How serious is the interaction between Azelastine and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic effects, especially in older adults. Counsel on driving and alcohol avoidance.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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