Drug interactions
Azelastine + Oxazepam
Severity: Moderate
Azelastine and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine may add to the sedative effects of oxazepam, impairing alertness and coordination. Older adults are particularly at risk of falls and confusion.
What this interaction means in plain words
Azelastine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through H1-receptor antagonism and GABA-A potentiation.
What to do
Monitor for excessive drowsiness and use the lowest effective oxazepam dose. Counsel against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Azelastine with Oxazepam?
MediHelp rates the interaction as moderate. Azelastine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azelastine may add to the sedative effects of oxazepam, impairing alertness and coordination. Older adults are particularly at risk of falls and confusion.
How serious is the interaction between Azelastine and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness and use the lowest effective oxazepam dose. Counsel against driving and alcohol.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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