Drug interactions
Azelastine-fluticasone + Belladonna and opium
Severity: Moderate
Azelastine-fluticasone and Belladonna and opium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine is a sedating antihistamine, and opium is an opioid that causes sedation and respiratory depression. Taken together they may add to drowsiness and impaired psychomotor performance, although systemic exposure from the nasal spray is modest.
What this interaction means in plain words
Azelastine-fluticasone and Belladonna and opium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from H1 antagonism and opioid receptor agonism.
What to do
Counsel the patient about drowsiness and advise against driving or operating machinery until the response is known. Monitor sedation and respiratory rate, especially when starting or increasing the opioid dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Frequently asked questions
Can I take Azelastine-fluticasone with Belladonna and opium?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Belladonna and opium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azelastine is a sedating antihistamine, and opium is an opioid that causes sedation and respiratory depression. Taken together they may add to drowsiness and impaired psychomotor performance, although systemic exposure from the nasal spray is modest.
How serious is the interaction between Azelastine-fluticasone and Belladonna and opium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about drowsiness and advise against driving or operating machinery until the response is known. Monitor sedation and respiratory rate, especially when starting or increasing the opioid dose.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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