Drug interactions
Azelastine-fluticasone + Buprenorphine buccal
Severity: Moderate
Azelastine-fluticasone and Buprenorphine buccal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine is an opioid partial agonist that causes sedation and respiratory depression, and azelastine adds sedative effects. Combined use may increase drowsiness and impair performance.
What this interaction means in plain words
Azelastine-fluticasone and Buprenorphine buccal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression from opioid receptor agonism and H1 antagonism.
What to do
Counsel patients on sedation and avoid driving until the response is known. Monitor sedation and respiratory status, particularly at initiation and with dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Frequently asked questions
Can I take Azelastine-fluticasone with Buprenorphine buccal?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Buprenorphine buccal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine is an opioid partial agonist that causes sedation and respiratory depression, and azelastine adds sedative effects. Combined use may increase drowsiness and impair performance.
How serious is the interaction between Azelastine-fluticasone and Buprenorphine buccal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on sedation and avoid driving until the response is known. Monitor sedation and respiratory status, particularly at initiation and with dose changes.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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