Drug interactions
Azelastine-fluticasone + Buprenorphine
Severity: Moderate
Azelastine-fluticasone and Buprenorphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine causes sedation and respiratory depression, and sedating antihistamines such as azelastine can add to central nervous system depression. The risk is higher with alcohol or other sedatives.
What this interaction means in plain words
Azelastine-fluticasone and Buprenorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Buprenorphine belongs to Musculoskeletal.
Why it happens
Additive central nervous system and respiratory depression from opioid and antihistamine activity.
What to do
Monitor sedation and respiratory status, especially when starting or increasing doses. Counsel against alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Frequently asked questions
Can I take Azelastine-fluticasone with Buprenorphine?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Buprenorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine causes sedation and respiratory depression, and sedating antihistamines such as azelastine can add to central nervous system depression. The risk is higher with alcohol or other sedatives.
How serious is the interaction between Azelastine-fluticasone and Buprenorphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, especially when starting or increasing doses. Counsel against alcohol and other sedatives.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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